Chymotrypsin is roughly the identical as trypsin. Each are concerned in protein amino acid metabolism enzymes, but additionally a hydrolase. Chymotrypsin is a proteolytic enzyme secreted by the pancreas and may shortly decompose denatured proteins. Its motion and use are much like that of enzyme trypsin. It has stronger decomposing potential, decrease toxicity and fewer hostile reactions than trypsin. The usage of chymotrypsin is broadly used and can be utilized for sprain, otitis media, rhinitis, sinusitis, pharyngitis, lung abscess and different remedies. It Can be utilized for surgical irritation, trauma, hematoma and abscess, and many others., it may also be used for tracheotomy. Chymotrypsin has a superb impact on many sufferers, making it simpler for cough. Pharmacological results of chymotrypsin The peptide chains of protein macromolecules will be cleaved into smaller molecular weight peptides, or act on the peptide ends of protein molecules to separate amino acids, and sure lipids will be hydrolyzed. Via this motion, fibrin and mucin will be hydrolyzed into polypeptides or amino acids within the sputum, making the viscous sputum liquefied and simple to cough up. It’s efficient for purulent or non-pyogenic sputum. As well as, chymotrypsin can chill out the ciliary ligament and dissolve the protein construction of sure tissues within the eye. Chymotrypsin additionally promotes the penetration of antibiotics and chemotherapeutic medication into lesions. Precautions 1.Intramuscular injections of chymotrypsin must be achieved earlier than allergy exams and intravenous injections are prohibited. 2.If allergic reactions happen, it must be stopped instantly and handled with antihistamines. 3.Chymotrypsin has a powerful toxicity to the retina. As a result of it could possibly trigger crystal injury, don’t let its liquid penetrate into the vitreous object. 4.The chymotrypsin is quickly inactivated by blood, so there have to be no coagulation of blood on the web site of administration 5.The chymotrypsin is secure within the strong state, however its answer is unstable. It could possibly lose 50% of its exercise after being left at room temperature for 9 days. Due to this fact, solely confect it earlier than the minute you need to use it. 6.The signs of glaucoma attributable to chymotrypsin could also be relieved by means of beta-blockers (comparable to timolol) or oral carbonic anhydrase inhibitors (comparable to acetazolamide) after the operation. 7.Because the titration of chymase was considerably decreased after ultrasonic nebulization, the inhalation time of chymotrypsin ultrasonic atomization must be managed inside 5 minutes. Antagonistic reactions: 1.Ophthalmology topical medication usually don’t trigger systemic hostile reactions, however may cause short-term enhance in intraocular strain, resulting in eye ache, uveitis and corneal edema. Any such glaucoma signs can persist 1 week, and may result in linear cloudiness of the cornea. Vitritis, iris pigmentation, uveitis, and cracking or delayed therapeutic of wounds. 2.Blood system: chymotrypsin may cause clotting dysfunction. 3.Different: (1) Intramuscular injection may cause anaphylactic shock. (2) chymotrypsin may cause histamine launch, leading to ache and swelling on the native injection web site.
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